Management of Chemical Substances

Proper Management of Pollutant Release and Transfer Register (PRTR) Substances

Chemical substances that are used in the research and development and production of pharmaceutical products include some substances (PRTR substances) subject to registration under the Law concerning Pollutant Release and Transfer Register (PRTR Law). The amounts of these substances handled, released into the environment and transferred as waste need to be understood and properly managed from the viewpoint of protecting the environment. Therefore, in addition to using our unique reagent management system to monitor the usage of reagents by the Eisai Group in Japan, we are also striving to reduce our usage of PRTR substances and to control their release into the environment. With regard to the usage of these substances exceeding the amount of the designated limit, we submit reports to the relevant prefectural governments without delay.

The amount of chemical substances used in the manufacturing processes depends largely on the volume of pharmaceutical products produced. To maintain the quality of active pharmaceutical ingredients, it is not easy to change manufacturing conditions after entering the commercial production phase. Therefore, we try to reduce the amount of chemical substances used by utilizing alternative solvents from the research and development stage and by developing synthesis processes that reduce the usage. At the same time, we actively promote the reuse of organic solvents and incorporate various means into the manufacturing processes to minimize their release into the atmosphere.

The total amount of PRTR substances handled by the Eisai Group in Japan during fiscal 2016 decreased 54.2% from fiscal 2015 to 258 tons. Notifications were made to authorities for seven substances, three less substances than in fiscal 2015. Because the inhouse production of vitamin E at the Kawashima Plant was terminated, water-soluble zinc compounds and isophytol no longer require reporting to the authorities. Additionally, there was a sharp decline in the amount of toluene handled.

Actual Use of Substances Subject to the PRTR System
Fiscal 2016 PRTR Data* for Eisai Group in Japan (Reported to Authorities)
  • *
    Data on the usage of chemical substances subject to the PRTR system

Volatile Organic Compounds (VOCs) Release Control

VOCs, such as ethyl acetate, acetone and methanol, are highly volatile and turn into gas in the atmosphere, and as is the case with NOx discharged from production plants, cause the generation of photochemical oxidants. In view of preventing air pollution, these substances need to be controlled to reduce their release into the atmosphere.

In response, main production plants and research facilities of the Eisai Group in Japan implement the same level of efforts as for PRTR substances to reduce the usage of VOCs and stipulate equipment operating procedures to minimize their release from production or research processes.

Management of Fluorocarbons

We are making efforts to prevent leakage of fluorocarbons from the standpoint of curbing depletionof the ozone layer and global warming. The Eisai Group in Japan carries out a survey on the amount of fluorocarbons used every other year at its production plants and research facilities and is systematically renewing equipment. Additionally, as a response to the Act on Rational Use and Proper Management of Fluorocarbons, we conduct regular inspections that also included offices for leakage of fluorocarbons from Class 1 Specified Products (commercial air conditioners and refrigeration and freezer equipment) that are subject to the Act. We also calculate the volume of leakage in each fiscal year and will make sure to report to the relevant authorities if the volume exceeds the reporting threshold.

Proper Management of Polychlorinated Biphenyl (PCB) Waste

We have made early application to Japan Environmental Storage & Safety Corporation (JESCO) and have been proceeding with the disposal of waste containing or contaminated with high-concentration PCB. Currently, we store PCB waste at two sites, the Honjo Facility and Kawashima Plant, and the table on the right lists PCB waste by item. As the disposal site for the fluorescent ballasts stored in Tokyo and Saitama Prefecture was changed to the JESCO Hokkaido operational site, we have completed re-registration for disposal of 661 fluorescent ballasts stored at the Honjo Facility and are now on a waiting list for detoxification treatment.

During fiscal 2016, we have completed the disposal of low-concentration PCB waste that had been stored at the Honjo Facility. We are reporting the storage status without delay to the relevant prefecture as required under the Law Concerning Special Measures Against PCB Waste and are properly storing PCB waste in enclosures with locks and warning signs and with measures to prevent vaporization, dispersion and leakage.