- For Print
- March 21, 2025
Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that it has obtained manufacturing and marketing authorization approval for the proton pump inhibitor "Pariet® S" (RX-to-OTC switch,1 pharmaceutical requiring guidance) in Japan for the indications of stomach pain, heartburn, and bloating.
"Pariet S" is the first over the counter (OTC) proton pump inhibitor (PPI2) gastric medicine containing rabeprazole sodium in an amount equivalent to that used in the prescription product.3 Rabeprazole sodium works directly on the proton pumps that produce stomach acid, effectively alleviating severe heartburn caused by gastric acid reflux and stomach pain due to excessive acid secretion. The medicine comes in small, easy-to-swallow tablets, with a once-daily dosage providing 24-hour relief.
Rabeprazole sodium, the active ingredient in “Pariet S”, is a PPI developed at Eisai’s Tsukuba Research Laboratories. The medicine was first launched in Japan in 1997 as a prescription pharmaceutical under the brand name “Pariet” and has since been approved more than 100 countries worldwide. It is widely prescribed to people struggling with acid-related disorders.
In recent years, there is a tendency for increased stomach acid secretion due to disrupted eating habits, stress, and a decline in the infection rate of Helicobacter pylori. Moreover, the number of individuals experiencing gastric acid reflux has grown, driven by age-related weakening of the lower esophageal sphincter. Eisai will introduce “Pariet S” as a new treatment option in the OTC gastric medication market, aiming to alleviate sever heartburn and discomfort caused by gastric acid related conditions, and strongly support people in the daily living domain who wish for a comfortable and secure daily life.
1 Pharmaceuticals that have been converted from prescription drugs to OTC
2 Proton Pump Inhibitor suppresses gastric acid secretion by inhibiting the “proton pump” which is the final step in the secretion process.
3 Contains rabeprazole 10mg per tablet
Media Inquiries:
Public Relations Department,
Eisai Co., Ltd.
+81-(0)3-3817-5120
[Notes to editors]
Product Outline
- 1. Product Name: “Pariet® S” (RX-to-OTC switch, pharmaceutical requiring guidance)
2. Ingredients:
Per daily dose of one tablet: rabeprazole sodium 10mg
Inactive Ingredients:
Magnesium oxide, talc, hydroxy propyl cellulose, D-mannitol, ethylcellulose, carnauba wax, carmellose calcium, glycerin esters of fatty acids, titanium oxide, iron sesquioxide, magnesium stearate, hypromellose phthalate
3. Indications and Usage:
Stomach pain, heartburn, and bloating (this medicine contains a proton pump inhibitor which suppresses
stomach acid secretion.)
4. Dosage and Administration:
Adults (15 years and older): 1 tablet once daily. Do not use this medicine consecutively for more than two weeks.