PIII Clinical Study Data on Chronic Constipation Treatment “GOOFICE® 5mg Tablet” Will Be Presented at DDW2018

Eisai Co., Ltd. (CEO: Haruo Naito; Headquarters: Tokyo, Japan) (hereinafter "Eisai"), Eisai’s subsidiary for gastrointestinal diseases EA Pharma Co., Ltd. (President & CEO: Yuji Matsue; Headquarters: Tokyo, Japan) (hereinafter “EA Pharma”) and Mochida Pharmaceutical Co., Ltd. (President: Naoyuki Mochida; Headquarters: Tokyo, Japan) (hereinafter “Mochida”) announce that an oral presentation on PIII clinical study data on “GOOFICE^® 5mg Tablet” (nonproprietary name: elobixibat hydrate; development code: AJG533, hereinafter “elobixibat”), a bile acid transporter inhibitor launched in Japan on April 19, 2018, will be given at Digestive Disease Week (DDW) 2018, June 2nd – 5th in Washington D.C., USA.

Elobixibat is a once-daily, orally available constipation treatment¹⁾ with a novel action mechanism. EA Pharma in-licensed this product from Albireo AB (Sweden). Elobixibat inhibits the bile acid transporter that regulates reabsorption of bile acids thereby increasing the flow of bile acids to the colon. The dual action of moisture secretion and bowel movement promotion by bile acids can facilitate defecation. Elobixibat is the world’s first pharmaceutical product approved for marketing with the above action mechanism. At DDW2018, safety results obtained from a PIII clinical study and a long-term dosing study will be presented. 

■DDW 2018 Presentation Title

Elobixibat was jointly developed by EA Pharma and Mochida. EA Pharma and Mochida distribute elobixibat under the same brand name “GOOFICE^® 5mg Tablet”, respectively, in Japan. EA Pharma and Eisai jointly provide proper use information of “GOOFICE^® 5mg Tablet” under a co-promotion agreement.
EA Pharma, Eisai and Mochida strive to make a further contribution to improve QOL for patients with chronic constipation through maximization of product value of “GOOFICE^® 5mg Tablet”.

• 1)
  Excluding structural disease-caused constipation

End

EA Pharma Co., Ltd., a subsidiary of Eisai Co., Ltd. for gastrointestinal disease area, was established in April 2016 by integration of the gastrointestinal business unit with more than 60 years’ history of the Eisai Group and the gastrointestinal business unit of the Ajinomoto Group having amino acid as its business core. EA Pharma is a gastrointestinal specialty pharma with a full value chain covering R&D, logistics and sales & marketing.
For more information on EA Pharma Co., Ltd., please see http://www.eapharma.co.jp/en/

Eisai Co., Ltd. is a leading global research and development-based pharmaceutical company headquartered in Japan. We define our corporate mission as "giving first thought to patients and their families and to increasing the benefits health care provides," which we call our human health care (hhc) philosophy. With approximately 10,000 employees working across our global network of R&D facilities, manufacturing sites and marketing subsidiaries, we strive to realize our hhc philosophy by delivering innovative products to address unmet medical needs, with a particular focus in our strategic areas of Neurology and Oncology.
For more information on Eisai Co., Ltd., please see https://www.eisai.com/

Mochida Pharmaceutical Co., Ltd. has been committed to research and development of innovative pharmaceutical products since its establishment thereby providing distinctive medicines to the medical field. Currently, the core pharmaceutical business focuses resources on the targeted areas of cardiovascular, obstetrics and gynecology, dermatology, psychiatry and gastroenterology, while also providing medicine for intractable disease as well as generics including biosimilars, to meet medical needs. 
For more information on Mochida Pharmaceutical Co., Ltd., please see 
http://www.mochida.co.jp/english/