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News Release

October 28, 2005
For Print (PDF 139KB)

Eisai Licenses E6020 Vaccine Adjuvant to Sanofi Pasteur SA

Eisai Co., Ltd. (Headquarters: Tokyo, President & CEO: Haruo Naito) announced today that on October 24 it signed license and supply agreements with Sanofi Pasteur SA (Headquarters: Lyon, France, President & CEO: David J Williams) for the use of Eisai's E6020 as an adjuvant to enhance the immune response to a broad range of vaccines.

As part of the agreement, Sanofi Pasteur obtained a non-exclusive license to incorporate the E6020 adjuvant in vaccines for use throughout all geographical regions. Sanofi Pasteur plans to test E6020, supplied by Eisai, in the development of new vaccine products. Under the terms of the agreement, Eisai will receive up-front license fees, success-based milestone payments and royalties from product sales.

E6020 is a synthetic substance that was discovered at the Eisai Research Institute of Boston, Inc. E6020 is a TLR-4 (Toll-like receptor-4) agonist that stimulates the host's natural immunity. It can be incorporated into various vaccines and is expected to enhance their effectiveness.

Sanofi Pasteur S.A. is a pharmaceutical company that specializes in developing and providing a broad range of vaccines against bacteria and viruses. In the future, as the need for vaccines increases worldwide, E6020 is expected to make significant contributions towards vaccine treatments.

<Notes to Editors>

What is an adjuvant?
An adjuvant or immunological adjuvant is a substance that enhances the immune response of vaccines. Basically, adjuvant means "enhancement", and when given in combination with an antigen, the adjuvant increases antibody production and initiates and directs the host immune response. An adjuvant is used in addition to vaccines.

What is TLR4(Toll-like receptor 4)?
TLR is a receptor that carries the host's natural immunity, and recognizes causal agents such as bacteria. There are more than 10 types of TLR that have been reported to date. TLR4 is also known as a receptor that can recognize endotoxin.