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News Release

FOR IMMEDIATE RELEASE
March 29, 2005

Dainippon Pharmaceutical and Eisai Conclude Agreement for the Development, Manufacture and Marketing of the Anti-Epileptic Agent Zonisamide in Asia

Dainippon Pharmaceutical Co., Ltd.
Eisai Co., Ltd.

Dainippon Pharmaceutical Co., Ltd. (Headquarters: Osaka City, President: Kenjiro Miyatake) and Eisai Co., Ltd. (Headquarters: Tokyo, President and CEO: Haruo Naito) announced on March 28, 2005, the conclusion of an exclusive agreement for the development, manufacture and marketing of zonisamide (generic name) in 14 Asian countries including China and Taiwan. Zonisamide is an anti-epileptic treatment created by Dainippon Pharmaceutical.

Zonisamide is an anti-epileptic agent characterized by a wide anti-seizure spectrum which is even effective against intractable epilepsy. In Japan, the drug was approved in 1989 and is marketed by Dainippon Pharmaceutical under the brand name Excegran(R). In the other Asian territories, the product was launched by Dong-A Pharmaeutical Co., Ltd. in 1992 in South Korea, and Eisai Korea Inc. has been marketing the product since the acquisition of marketing rights on February 25, 2005.

In the United States and Europe, Elan Corporation, plc. had licensed zonisamide from Dainippon Pharmaceutical and had since marketed it under the product name Zonegran(R) in the U.S. while continuing development in Europe. In March 2004, Eisai obtained manufacturing, development and marketing rights for Zonegran(R) upon the completion of an strategic product acquisition agreement with Elan. Currently in the U.S., Eisai Inc., a subsidiary in the U.S., markets the drug under the name Zonegran(R), which has been successfully penetrating the U.S. market. In Europe, an Eisai U.K. subsidiary, Eisai Ltd. obtained marketing authorization approval of Zonegran(R) from the European Commission on March 10, and will develop and expand Zonegran(R) business in the enlarged EU market.

Dainippon Pharmaceutical and Eisai Co., Ltd. expect that through this territorial expansion agreement, Eisai will also expand business opportunities in Asian countries by utilizing its marketing expertise accumulated through experience in the U.S. and Europe to fulfil patients' needs and make further contributions to the benefits that the drug can provide throughout the Asian region.


Contacts:

Public Relations Division Corporate Communications Department
Dainippon Pharmaceutical Co., Ltd. Eisai Co., Ltd
2-6-8, Dosho-machi, Chuo-ku,  4-6-10, Koishikawa, Bunkyo-ku,
Osaka City 541-8524 Tokyo 112-8088
81-6-6203-1407 81-3-3817-5120