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News Release

FOR IMMEDIATE RELEASE
September 1, 2017

EISAI TO PRESENT ABSTRACTS ON ONCOLOGY PRODUCTS AND PIPELINE AT ESMO 2017 CONGRESS
THREE ABSTRACTS ON LENVIMA® (LENVATINIB) TO BE PRESENTED IN ORAL SESSION

Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that a series of abstracts highlighting updates regarding its in-house discovered Lenvima®/Kisplyx® (lenvatinib mesylate, “lenvatinib”, selective inhibitor of receptor tyrosine kinases with a novel binding mode), Halaven® (eribulin mesylate, “eribulin”, halichondrin class microtubule dynamics inhibitor), and E7046 (prostaglandin E2 receptor EP4 inhibitor) will be presented during the European Society for Medical Oncology (ESMO) 2017 Congress , taking place in Madrid, Spain, from September 8 to 12, 2017.

At the ESMO 2017 Congress, there will be an oral presentation on the results of a health-related Quality of Life analysis of patients from a Phase III clinical trial (REFLECT/Study 304) of lenvatinib versus sorafenib for unresectable hepatocellular carcinoma, and a separate oral presentation on the results of an analysis of biomarkers from the same study. In addition, there will be an oral presentation on the results of the metastatic renal cell carcinoma cohort from a Phase Ib/II clinical trial (Study 111) of lenvatinib in combination with anti-PD-1 antibody pembrolizumab.

There are six poster presentations scheduled, including presentations on the results of a primary analysis of a Phase II clinical trial of lenvatinib in biliary tract cancer, and the results of a Phase I clinical trial of E7046.

Eisai positions oncology as a key therapeutic area, and is aiming to discover revolutionary new medicines with the potential to cure cancer. Eisai will continue to create innovation in the development of new drugs based on cutting-edge cancer research, as it seeks to contribute further to addressing the diverse needs of, and increasing the benefits provided to, patients with cancer, their families, and healthcare providers.

Eisai products and pipeline selected for major presentations at the ESMO 2017 Congress.
Oral Presentations:
ProductAbstract title and scheduled presentation date and time (local time)
Lenvatinib

Abstract No: 847O
A phase 1b/2 trial of lenvatinib plus pembrolizumab in patients with renal cell carcinoma

Oral Presentation | September 9 (Sat), 10:15-10:30
Lenvatinib

Abstract No: LBA30
Analysis of serum biomarkers (BM) in patients (pts) from a phase 3 study of lenvatinib (LEN) vs sorafenib (SOR) as first-line treatment for unresectable hepatocellular carcinoma (uHCC)
Oral Presentation | September 10 (Sun), 11:45-12:00
Lenvatinib

Abstract No: 618O
Health-related quality of life (HRQOL) and disease symptoms in patients with unresectable hepatocellulcar carcinoma (HCC) treated with lenvatinib (LEN) or sorafenib (SOR)
Oral Presentation | September 10 (Sun), 12:00-12:15
Major Poster Presentations:
ProductAbstract title and scheduled presentation date and time (local time)
Eribulin

Abstract No: 292P
Prospective observational study of peripheral neuropathy in breast cancer patients treated with eribulin
Poster Presentation | September 11 (Mon), 13:15-14:15
Lenvatinib

Abstract No: 722P
A phase 2 study of lenvatinib (LEN) monotherapy as second-line treatment in unresectable biliary tract cancer: Primary analysis results
Poster Presentation | September 9 (Sat), 13:15-14:15
Lenvatinib

Abstract No: 878P
Comparing ITC results from lenvatinib plus everolimus for second-line treatment of advanced/metastatic renal cell carcinoma: Crossover versus no crossover
Poster Presentation | September 10 (Sun), 13:15-14:15
Lenvatinib
Abstract No: 707P
Network Meta-Analysis (NMA) of Treatments for Unresectable Hepatocellular Carcinoma (uHCC)
Poster Presentation | September 9 (Sat), 13:15-14:15
Lenvatinib

Abstract No: 434PD
Impact of duration of dose interruption on the efficacy of lenvatinib (LEN) in a phase 3 study in patients (pts) with radioiodine refractory differentiated thyroid cancer (RR-DTC)
Poster Presentation | September 11 (Mon), 11:00-12:00 (Poster Discussion: 11:00-11:25)
E7046

Abstract No: 373PD
Phase 1 Study of E7046, a PGE2 Receptor EP-4 inhibitor that targets immunosuppressive myeloid cells in the tumor microenvironment
Poster Presentation | September 9 (Sat), 16:30-18:00 (Poster Discussion: 17:30-18:00)

Media Inquiries:
Public Relations Department,
Eisai Co., Ltd.
+81-(0)3-3817-5120