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Production and Logistics (Demand Chain Systems)

Establishing a Global, Patient-Oriented Production System

“The quality of every single tablet, capsule, and ampule that we produce is integral to the life of the patient.”

This is Eisai's general policy on product quality, with each employee keenly aware that every drug manufactured by us directly affects patients' lives. It is this conviction that is reflected in every aspect of our production activities and we believe that as long as there are people around the world in need of medicine, there exists a mission and a responsibility to continue to assure the stable supply of high-quality pharmaceutical products. To achieve this, the Eisai Group consistently strives for high quality through its introduction of a robust management system that oversees all processes from drug substance and formulation research to production and distribution.

Eisai's production division consists of ten manufacturing sites around the world, five Product Units based on therapeutic area, three Management Functional Units to support their activities and Headquarters (Strategic Planning, Cost & Budget Control, Talent Management). Under this structure, we implement end-to-end production which enables us to grasp patients' true needs in a timely manner and deliver products that realize satisfaction as soon as possible.

Product Units work to identify the specific needs of patients in each therapeutic area, and by aiming to provide formulations that address these needs and improve the convenience of packaging, as well as utilizing the latest technologies at various stages, realize the creation of products that lead to Customer Joy. In addition, we will optimize management at every stage, including the procurement of raw materials to production, packaging and distribution. All these production activities are fully supported by our Quality Assurance, CMO Management and Technology functions.

“Everything we do should reflect the needs of patients, their families, and customers”. Based on this belief, we continue to work toward ensuring the stable supply of high-quality medicines throughout the world.

*What is the demand chain?
Under the concept of the “demand chain,” besides the production and supply of products, the goal is to build systems to ensure that production activities and product improvements are actively geared to meeting the demands of patients.

A Global Structure to Ensure the Stable Supply of Medicines

The system that we have introduced enables us to distribute products on a global scale from multiple sites while also ensuring a stable supply of high-quality medicines to people around the world in times of emergency.

■Manufacturing Sites Worldwide

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Japan Manufacturing Sites

Kawashima Plant

Location Kawashima-Takehaya, Kakamigahara, Gifu
Site Area 466,474m2
Year Completed 1966
Characteristics Manufactures prescription drugs (including film-coated tablets, fine granules and capsules) for domestic and overseas supply. Its manufacturing facilities have introduced an automated boxing system, with advanced packaging lines equipped with automated robotic arms and automated conveyor systems.

Kashima Plant

Location Sunayama, Kamisu, Ibaraki
Site Area 239,664m2
Year Completed 1984
Characteristics Global production center for APIs. Performs dual functions of industrial research and API production as well as inspection of API production processes with the aim of commercial production at earlier stages of drug development. Continues to achieve in product quality improvement, stable supply, and environmental conservation through efficiency management changes to its manufacturing processes.

EA Pharma Co., Ltd. Fukushima Plant

Location Shirasaka, Shirakawa, Fukushima
Site Area 67,000m2
Year Completed 1986
Characteristics Manufactures prescription drugs. Has the capacity to manufacture a diverse range of formulations including tablets, granules, ointments and suppositories.

* The business operations at the Misato Plant were transferred to Bushu Pharmaceuticals Ltd. as of March 31, 2014. With regard to parenteral formulations production, however, Eisai leases back the manufacturing facility and continues production.

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Global Manufacturing Sites

Hatfield Plant (U.K.)

Location European Knowledge Centre, Hatfield, Hertfordshire, U.K.
Site Area 60,000m2
Year Completed 2009
Characteristics Having both packaging and oral solid dose manufacturing capabilities, the plant especially excels in handling packaging of low-volume multilingual products in Europe, where there is a particularly high linguistic diversity.
With regard to global products such as Halaven, Lenvima and Fycompa, the plant functions as a global production center, having commenced supply to countries in the Middle East, Africa, the Americas and Asia in addition to Europe.

Suzhou Factory (China)

Location Suzhou, Jiangsu, China
Site Area 25,171m2
Year Completed 1998
Characteristics Formulation manufacturing hub mainly responsible for handling production and packaging of prescription drugs for the Chinese market. To further ensure the stable supply and improve manufacturing efficiency, a Parenteral Formulation facility was built within the Suzhou Industrial Park. The decision was also made to build a new oral solid dose production facility within the same industrial park.

Benxi Plant (China)

Location Benxi, Liaoning, China
Site Area 113,595m2
Year Completed 2011
Characteristics Manufacture APIs and has the capacity to manufacture a variety of formulations such as tablets, capsules, granules, liquids and freeze-dried injections.

Vizag Plant (India)

Location Vizag, Andhra Pradesh, India
Site Area 200,000m2
Year Completed 2009
Characteristics Handles dual functions of API production and research into formulation production and APIs. Jointly responsible for Eisai's global API supply and serves as a supply center not only for emerging economies and the developing world but also developed countries, including Japan. In addition, the plant carries out a key role in Eisai's efforts to realize affordable pricing, and began production of antifilariasis medicine in August 2013 to provide at price zero to the World Health Organization (WHO) as a part of these efforts.

Bogor Factory (Indonesia)

Location Bogor, West Java, Indonesia
Site Area 30,000m2
Year Completed 1987
Characteristics Manufacturing site in charge of production and packaging of prescription drugs. There are currently plans to expand the market beyond Indonesia to include all the ASEAN countries in the future.

Baltimore Plant (U.S.)

Location Baltimore, Maryland, U.S.
Site Area 8,455m2 (Gliadel Manufacturing area 1,840m2)
Year Completed 1995
Characteristics The plant is responsible for the global supply of Gliadel Wafer, a biodegradable implant used during surgery for the treatment of brain cancer. The plant has received manufacturing approval from various countries worldwide, including Japan, the U.S. and EU member states.

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