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News Release

FOR IMMEDIATE RELEASE
April 16, 2010
For Print (PDF 50KB)

EISAI SIGNS LICENSE AGREEMENT WITH ALMIRALL FOR THE DEVELOPMENT, MANUFACTURING AND MARKETING OF CINITAPRIDE IN CHINA


Eisai Co., Ltd. (Headquarters: Tokyo, President and CEO: Haruo Naito, “Eisai”) announced today that the company has signed a license agreement with Almirall, S.A. (Headquarters: Barcelona, Spain, Chairman and Managing Director: Jorge Gallardo, “Almirall”) concerning the development, manufacturing and marketing of the gastroprokinetic agent cinitapride tartrate (generic name).

Under the terms of the agreement, Eisai shall obtain from Almirall the exclusive rights to develop, manufacture and market cinitapride in China. This will be the second agreement that Eisai and Almirall have signed following the agreement concluded in 2001 concerning the antiallergic agent Kestine (generic name: ebastine), also for China.

Cinitapride. coming from Almirall’s R&D, is an orthopramide with prokinetic activity on the gastrointestinal tract with marked procholinergic action that improves gastrointestinal motility. By blocking the presynaptic serotonin receptors, serotonin release is increased, thus enhancing serotonergic activity. Its antidopaminergic activity also contributes to stimulate the release of acetylcholine by blocking dopamine receptors, thereby improves upper gastrointestinal function. In Spain, cinitapride is indicated for treating mild to moderate dysmotility-type dyspepsia and also as an adjunctive therapy for gastroesophageal reflux disease in patients for whom the proton pump inhibitor has shown to be insufficient.

Eisai considers China as one of the Company’s focused regions with high growth potential and is working to expand business that addresses not only its global areas of therapeutic focus, but also its franchise tailored to the local disease structures in China. Gastrointenstinal franchise is one such areas, and the addition of cinitapride will further strengthen the Company’s existing gastrointestinal product portfolio together with the currently marketed gastritis/gastric ulcer treatment Selbex® and hepatic disease/allergic disease agents Stronger Neo-Minophagen C® and Glycyron® Tablets, as well as two pipeline products, chronic hepatitis B treatment Clevudine and branched-chain amino acid formula Livact® Granules.

Eisai will continue to work closely with Almirall on the development of cinitapride with the hope of delivering the compound to patients in China in a timely manner.

[Please refer to the following notes for information on cinitapride and Almirall]

Media Inquiries:
Public Relations Department,
Eisai Co., Ltd.
+81-(0)3-3817-5120


< Notes to Editors >

About Cinitapride (Product Outline in Spain)

 Product Name:
Cidine®

 Generic Name:
Cinitapride

 Formulations:
Tablet, liquid, packaged powder for single-unit dose

 Indications:
-Treatment of mild to moderate dysmotility-type dyspepsia
-Adjunctive therapy for gastroesophageal reflux disease in patients for whom the proton pump inhibitor has shown to be insufficient

 Administration and Dosage:
-Tablet
For adult patients aged 20 and older: one tablet taken orally three times a day, 15 minutes before each meal.

-Liquid
For adult patients aged 20 and older: two spoonfuls taken orally three times a day, 15 minutes before each meal.

-Packaged Powder for single-unit dose
For adult patients aged 20 and older: one packet taken orally three times a day, suspended in one glass of water, 15 minutes before each meal.

 Adverse Events
Extrapyramidal symptoms (with facial, cervical and lingual muscle spasms), pruritus and rash, etc


About Almirall

Almirall is an international pharmaceutical company based on innovation and committed to health. Headquartered in Barcelona, Spain, it researches, develops, manufactures and commercializes its own R&D and licensed drugs with the aim of improving people’s health and well-being. The therapeutic areas on which Almirall focuses its research resources are related to the treatment of asthma, COPD (Chronic Obstructive Pulmonary Disease), rheumatoid arthritis, multiple sclerosis, psoriasis and other dermatological conditions. Almirall’s products are currently present in over 70 countries while it has direct presence in Europe and Latin America through 11 affiliates.

For more information on Almirall, please visit the website at: www.almirall.com